Tag: Studies

Study: Cannabis Improves Outcomes in Opioid-Dependent Subjects Undergoing Treatment

Study: Cannabis Improves Outcomes in Opioid-Dependent Subjects Undergoing Treatment

Cannabis use is associated with improved outcomes in opioid-dependent subjects undergoing outpatient treatment, according to data published online ahead of print in the journal Drug and Alcohol Dependence.

Researchers at Columbia University assessed the use of cannabinoids versus placebo in opioid-dependent subjects undergoing in-patient detoxification and outpatient treatment with naltrexone, an opiate receptor antagonist.

Investigators reported that the administration of oral THC (dronabinol) during the detoxification process lowered the severity of subjects’ withdrawal symptoms compared to placebo, but that these effects did not persist over the entire course of treatment.

By contrast, patients who consumed herbal cannabis during the outpatient treatment phase were more readily able to sleep, were less anxious, and were more likely to complete their treatment as compared to those subjects who did not.

“One of the interesting study findings was the observed beneficial effect of marijuana smoking on treatment retention,” authors concluded. “Participants who smoked marijuana had less difficulty with sleep and anxiety and were more likely to remain in treatment as compared to those who were not using marijuana, regardless of whether they were taking dronabinol or placebo.”

The findings replicate those of two prior studies, one from 2001 and another from 2009, reporting greater treatment adherence among subjects who consumed cannabis intermittently during outpatient therapy.

Population data from states where medicinal cannabis is permitted report lower rates of opioid-abuse and mortality as compared to those states where the plant is prohibited. Clinical data and case reports also indicate that the adjunctive use of cannabis may wean patients from opiates while successfully managing their pain. Survey data of state qualified medical cannabis patients demonstrates that subjects with access to the plant often substitute it for opioids because they perceive it to possess fewer adverse side effects.

Overdose deaths involving opioids have increased dramatically in recent years. While fewer than 4,100 opiate-induced fatalities were reported for the year 1999, by 2010 this figure rose to over 16,600 according to an analysis by the US Centers for Disease Control.

An abstract of the study, “The effects of dronabinol during detoxification and the initiation of treatment with extended release naltrexone,” appears online here.


Thank you for visiting MDMMCC.com, the premier Medical Marijuana Certification Center in Maryland. Our Mission at the Maryland Medical Marijuana Certification Clinics (MDMMCC) is to provide the certification necessary for qualified patients to obtain Medical Marijuana in compliance with the Maryland Medical Marijuana Laws in the State of Maryland.  MDMMCC will have offices open throughout Maryland.

Study: Cannabinoids are Safe, Effective for Pain Treatment

Study: Cannabinoids are Safe, Effective for Pain Treatment

Cannabinoids are safe and effective for the treatment of chronic pain, according to the results of a systematic review of randomized controlled trials published in the Journal of Neuroimmune Pharmacology.

Investigators from Dalhousie University in Halifax, Nova Scotia and McGill University in Montreal evaluated the results of 11 placebo-controlled trials conducted between the years 2010 and 2014. Trials assessed the use of various types of cannabinoid preparations, including herbal cannabis, liquid and oral cannabis extracts, and nabilone (a synthetic analog of THC), in pain treatment.

Cannabinoids possessed “significant analgesic effects” and were “well tolerated” in the majority of studies reviewed.

Authors concluded, “The current systematic review provides further support that cannabinoids are safe, demonstrate a modest analgesic effect and provide a reasonable treatment option for treatment chronic non-cancer pain.”

A 2011 review of 18 separate randomized trials evaluating the safety and efficacy of cannabinoids for pain management similarly reported, “[C]annabinoids are a modestly effective and safe treatment option for chronic non-cancer (predominantly neuropathic) pain.”

In September, Canadian researchers reported that pain patients who consumed herbal cannabis daily for one-year experienced decreased analgesia and no increase in serious adverse side effects compared to matched controls.

An abstract of the study, “Cannabinoids for the treatment of chronic non-cancer pain: An updated systematic review of randomized controlled trials,” appears online here.


Thank you for visiting MDMMCC.com, the premier Medical Marijuana Certification Center in Maryland. Our Mission at the Maryland Medical Marijuana Certification Clinics (MDMMCC) is to provide the certification necessary for qualified patients to obtain Medical Marijuana in compliance with the Maryland Medical Marijuana Laws in the State of Maryland.  MDMMCC will have offices open throughout Maryland.

Study: Marijuana Consumers Less Likely To Suffer From Metabolic Syndrome

Study: Marijuana Consumers Less Likely To Suffer From Metabolic Syndrome

Current consumers of cannabis are 50 percent less likely to suffer from metabolic syndrome as compared to those who have never used the substance, according to findings published online ahead of print in The American Journal of Medicine.

Metabolic syndrome is a group of risk factors, including high blood pressure, high blood sugar, unhealthy cholesterol levels, and abdominal fat, which are linked to increased risk of heart disease and/or type 2 diabetes, among other serious health consequences.

Investigators from the University of Miami Leonard M. Miller School of Medicine analyzed the association between cannabis use and metabolic syndrome in a cohort of nearly 8,500 subjects aged 20 to 59 who participated in the 2005-2010 National Health and Nutrition Examination Surveys. Researchers classified subjects as suffering from metabolic syndrome if they possessed more than three of the following symptoms: elevated fasting glucose levels, high triglycerides, low HDL cholesterol, elevated systolic/diastolic blood pressure, and increased waist circumference.

Among subjects with no history of cannabis use, 19.5 percent met the criteria for metabolic syndrome. By contrast, 17.5 percent of former users and only 13.8 percent of current users met the criteria.

“Among emerging adults, current marijuana users were 54 percent less likely than never users to present with metabolic syndrome,” investigators reported. Specifically, mean fasting glucose levels were significantly lower among current marijuana users when compared to never users, while waist circumference was significantly lower among males who reported current marijuana use when compared to those with no cannabis use history.

“These findings have important implications for the nation as marijuana use becomes more accepted and we simultaneously face multiple epidemics of obesity, cardiovascular disease and diabetes,” authors concluded.

The findings are consistent with those of previous observational studies showing an inverse relationship between cannabis use and diabetic markers, and support previous population data showing that those who use cannabis typically possess smaller waist circumference and lower body mass index than those who do not.

An abstract of the study, “Metabolic Syndrome among Marijuana Users in the United States: An Analysis of National Health and Nutrition Examination Survey Data,” is online here.


Thank you for visiting MDMMCC.com, the premier Medical Marijuana Certification Center in Maryland. Our Mission at the Maryland Medical Marijuana Certification Clinics (MDMMCC) is to provide the certification necessary for qualified patients to obtain Medical Marijuana in compliance with the Maryland Medical Marijuana Laws in the State of Maryland.  MDMMCC will have offices open throughout Maryland.

Survey: Majority of Pharmacy Students Say Legalize Marijuana for Medical Purposes

Survey: Majority of Pharmacy Students Say Legalize Marijuana for Medical Purposes

LAWRENCE, KS — Nearly six out of ten pharmacy students believe that the therapeutic use of cannabis should be legal, according to survey data published in the American Journal of Pharmaceutical Education.

Investigators at the University of Kansas assessed students’ knowledge and attitudes toward the medical use of cannabis. Three hundred and eleven UK pharmacy students completed the survey.

Fifty-nine percent of respondents said, “[M]arijuana should be legalized for medicinal uses.” Respondents who acknowledged having previously consumed marijuana themselves were far more likely to support legalizing cannabis therapy as compared to those with no prior history of use.

However, the majority of respondents also acknowledged that they felt uncomfortable answering consumers’ questions specific to the plant’s safety and efficacy. Few respondents reported receiving any school instruction specific to cannabis, and 90 percent of those surveyed indicated that more instruction on medical marijuana should be incorporated into their curriculum.


Thank you for visiting MDMMCC.com, the premier Medical Marijuana Certification Center in Maryland. Our Mission at the Maryland Medical Marijuana Certification Clinics (MDMMCC) is to provide the certification necessary for qualified patients to obtain Medical Marijuana in compliance with the Maryland Medical Marijuana Laws in the State of Maryland.  MDMMCC will have offices open throughout Maryland.

ADHD Patients Successfully Treated with Cannabis

ADHD Patients Successfully Treated with Cannabis

The use of herbal cannabis eases symptoms in adults suffering from ADHD (attention deficiency hyperactivity disorder), according to clinical trial data presented at an international symposium on cannabinoid therapeutics last month.

German researchers evaluated the effects of marijuana in 30 patients suffering from ADHD. All of the subjects participating in the trial had previously tried various forms of conventional therapies, but their condition had proven resistant to alternative treatments. Under German law, patients who are unresponsive to government-approved medications may apply with the Health Ministry for a waiver to use medicinal cannabis.

Subjects experienced a mitigation of ADHD symptoms, including “improved concentration and sleep, and reduced impulsivity,” following cannabis therapy, researchers reported. Twenty-two of the 30 patients in the cohort elected to discontinue their use of pharmaceutical drugs during the study period—instead opting to solely use cannabis to treat their symptoms.

Despite anecdotal reports regarding the use of marijuana to address ADHD symptoms, clinical data on the subject is minimal and, to date, no state includes the disorder as a qualifying condition eligible for cannabis therapy. (Only two jurisdictions, California and Washington, D.C. permit doctors to recommend medicinal marijuana solely at his or her discretion.) A prior case study, published in 2008, reported that the administration of oral THC (in the form of the FDA-approved drug Marinol) “had a positive impact on performance, behavior and mental state” of a 28-year-old subject diagnosed with the condition.

Attention deficiency hyperactivity disorder is a condition that it typically identified in children and may persist into adulthood. The disorder is typically characterized by hyperactivity, impulsivity, forgetfulness, difficulty paying attention and a lack of organization and prioritization skills. Approximately 11 percent of school-aged children in the U.S. have been diagnosed with the disorder, which is commonly treated with the use of amphetamines or amphetamine derivatives.


Thank you for visiting MDMMCC.com, the premier Medical Marijuana Certification Center in Maryland. Our Mission at the Maryland Medical Marijuana Certification Clinics (MDMMCC) is to provide the certification necessary for qualified patients to obtain Medical Marijuana in compliance with the Maryland Medical Marijuana Laws in the State of Maryland.  MDMMCC will have offices open throughout Maryland.

Presence of THC Metabolites in Hair Not Necessarily Indicative of Marijuana Ingestion

Presence of THC Metabolites in Hair Not Necessarily Indicative of Marijuana Ingestion

FREIBURG, GERMANY — THC metabolites may be present in the hair of individuals who have never ingested cannabis, according to clinical trial data published online in the journal Nature, Scientific Reports.

Investigators at University of Freiburg Medical Center in Germany assessed hair samples in human subjects with varying degrees of cannabis exposure. Researchers reported THC metabolites can be transferred from cannabis users to non-users via close body contact.

Authors concluded:

“Our studies show that all three cannabinoids [THC, THC-A, and THC-COOH] can be present in hair of non-consuming individuals because of transfer through cannabis consumers, via their hands, their sebum/sweat, or cannabis smoke. This is of concern [in] child-custody cases as cannabinoid findings in a child’s hair may be caused by close contact to cannabis consumers rather than by inhalation of side-stream smoke.”


Thank you for visiting MDMMCC.com, the premier Medical Marijuana Certification Center in Maryland. Our Mission at the Maryland Medical Marijuana Certification Clinics (MDMMCC) is to provide the certification necessary for qualified patients to obtain Medical Marijuana in compliance with the Maryland Medical Marijuana Laws in the State of Maryland.  MDMMCC will have offices open throughout Maryland.